MainTumors are complex tissues composed of cancerous and non-cancerous cells in a hypoxic and nutrient-deprived microenvironment. The tumor microenvironment contains heterogeneous cell populations, including immune cells, mesenchymal support cells and matrix components that contribute to tumor growth and progression1. To survive this environment, tumors are capable of reprogramming metabolic pathways to better use available substrates in the surrounding tumor microenvironment, ultimately becomin...