Highlights•We tested VNS combined with prolonged exposure therapy as a treatment for PTSD.•Nine individuals received VNS therapy with a miniaturized device.•VNS therapy was safe and feasible to deliver.•After therapy, all participants no longer met the criteria for PTSD diagnosis.•These findings support the performance of a randomized controlled trial.AbstractBackgroundPosttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We d...