IntroductionArtificial sweeteners (ASWs), also known as non-nutritive sweeteners (NNSs), as alternatives to caloric sugar are much appreciated by consumers. Aspartame (APM), as one of the commonly used sweeteners,1 is approximately 200 times sweeter than sucrose, and its calorific value in added foods and beverages is nearly zero.2 According to the FDA, maximal recommended daily intake of APM is 40 mg/kg bodyweight in Europe and 50 mg/kg bodyweight in the United States.2,3 Unfortunately, uninten...