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Healthspan Research Review | Two Waves of Aging: How Midlife Biomolecular Shifts Accelerate Decline

The Evolution of Aging Models—From Damage to Dynamic WavesFor decades, scientists have proposed various models to explain the mechanisms underlying aging. The damage-accumulation theory, for example, posits that aging results from the gradual buildup of molecular and cellular damage, including oxidative stress, DNA mutations, and protein misfolding. In contrast, the quasi-programmed aging framework suggests that biological pathways optimized for growth and reproduction during early life later be...

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