Deletions between on-target loci upon treatment with Cas9-sgRNA1 RNPs in PLB-985 NCF1 ΔGT cells. Credit: Communications Biology (2024). DOI: 10.1038/s42003-024-06959-z The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic defects—as in the case of chronic granulo...