Audio: IntroductionSome backgroundThe hard stuffThe relevance of toxicity datasets to the clinical problemMethodological problems in toxicity datasetsIntraspecies toxicity variability Toxicity synergism ConclusionsThere are now (claimed) foundation models for protein sequences, DNA sequences, RNA sequences, molecules, scRNA-seq, chromatin accessibility, pathology slides, medical images, electronic health records, and clinical free-text. It’s a dizzying rate of progress.But there’s a few problem...