Structures of MCX-66, MCX-91 and MCX-128 in complex with the wild-type T. thermophilus 70S ribosome. Credit: Nature Chemical Biology (2024). DOI: 10.1038/s41589-024-01685-3 A new antibiotic that works by disrupting two different cellular targets would make it 100 million times more difficult for bacteria to evolve resistance, according to new research from the University of Illinois Chicago. For a new paper in Nature Chemical Biology, researchers probed how a class of synthetic drugs called macr...