Graphical abstract. Credit: Journal of the American Chemical Society (2025). DOI: 10.1021/jacs.5c05004 Cortisol is a crucial hormone that regulates many important bodily functions like blood pressure and metabolism, and imbalances of this stress hormone can lead to health problems. Traditionally, cortisol levels must be measured in a doctor's office or other clinical setting. But a new advance in the design of artificial biosensors paves the way for point-of-care testing and diagnoses with far g...